バイオグラフィー

デレティック博士は、ニューメキシコ大学医学部の分子遺伝学および微生物学科の学科長です。 彼はベオグラード、パリ、シカゴで学部、大学院(Ph.D.)、ポスドクの教育を受けました。 デレティック博士の科学への主な貢献は、感染と免疫におけるオートファジーの役割に関する彼のチームによる研​​究から来ています。 デレティック博士は、NIHが資金提供するオートファジー、炎症、代謝(AIM)センターオブバイオメディカルリサーチエクセレンス(CoBRE)のディレクターです。 AIMセンターは、オートファジーの研究を国内外で推進し、この分野の上級専門家とともにジュニア教員の幹部を育成して、基本的なメカニズムと、オートファジーがさまざまな人間の病気や健康状態とどのように交差するかを研究することを目的としています。

身上書

Dr. Deretic is an international authority on the role of autophagy in inflammation and immunity. The connections between autophagy and tuberculosis began with Dr. Deretic’s seminal publication on the role of autophagy in control of Mycobacterium tuberculosis (Mtb) published in Cell in 2004. This was followed by sustained development of the filed including Dr. Deretic’s publications in Science 2006, Nature Cell Biology 2010, a series of studies in Immunity, and more recent studies in 2015-2017 published in Molecular Cell, JCB, Developmental Cell, EMBO J, etc. Dr. Deretic has been consistently invited to summarize the new field of autophagy as an innate immunity and anti-inflammatory process as exemplified in the earliest reviews on this topic in 2005 and most recently in Nature Reviews Immunology (2013), JCI (2015) J. Exp. Med. (2015), and JLB (2016). His group reported a broad role of proteins termed TRIMs (82 members in humans) as autophagic regulator-receptors, published in a series articles in Developmental Cell (2014, 2016) J. Cell Biol. (2015), etc. Dr. Deretic’s lab reported on the role of specific SNAREs in controlling how autophagy terminates - in secretion (EMBO J 2017) or degradation (J. Cell Biol, 2018). Most recently, Dr. Deretic and colleagues have uncovered the role of cytosolic lectins, termed galectins, in direct control of mTOR and AMPK, the most upstream regulators of autophagy and master regulators of cellular metabolism (Molecular Cell, 2018). In terms of translational efforts, Dr. Deretic’s group has identified a series of potential therapeutics aimed at autophagy, ready for repurposing (Nature Comm., 2015; and US patent 9572820). Dr. Deretic was 2012 Chair of Gordon Research Conference on Autophagy, and will be the lead organizer/chair of the 2019 Keystone Symposium on Autophagy.

As a Chairman of a basic science department in a medical school and Director of the Autophagy, Inflammation and Metabolism (AIM) center on autophagy, Dr. Deretic has considerable organizational, fiscal, programmatic, mentoring, and networking skills. While his administrative duties are many, his own research has been exceptionally productive and at a cutting edge of international science. Dr. Deretic’s has demonstrated abilities to balance administrative responsibilities with high-end scientific endeavors. Dr. Deretic to this day works experimentally in the laboratory, specializing in high content and quantitative microscopy.

専門分野

オートファジー
結核
HIV
微生物学
免疫学

実績と賞

Annual Research Lecturer (UNM) 2022
NIH MERIT award 2018
Basic Science Research Award (UNM HSC) 2015

Undergraduate: Dean’s list 1974-1978
Graduate: October Award, Belgrade, 1978
FEBS fellowship, Paris, France, 1980

主要な出版物

雑誌の記事
Gutierrez, M, G Master, S, S Singh, S, B Taylor, G, A Colombo, M, I Deretic, Vojo, 2004 Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. Cell, vol. 119, Issue 6, 753-66

ジェンダー

男性

ESL, ビジネスESL <br> 中国語/フランス語、その他

  • 英語

教えられたコース

免疫学、微生物学、感染症に関連するUMEフェーズIコース

Undergraduate medical education

Spring 2022, Microbiology Immunology in UME Phase 1 for MS2025 (medical students graduating in 2025). CBL/TBL (Cannon/Mandell course directors)

Spring 2021, Microbiology Immunology in UME Phase 1 for MS2024 (medical students graduating in 2024). CBL/TBL (Cannon/Mandell course directors)

Spring 2020, Microbiology Immunology in UME Phase 1 for MS2024 (medical students graduating in 2024). CBL/TBL (Cannon/Mandell course directors)

Spring 2019, Microbiology Immunology in UME Phase 1 for MS2025 (medical students graduating in 2025). CBL/TBL (Chackerian/Cannon course directors)

Fall 2018, Infectious disease block, UME Phase 2, PBL tutorials 10 sessions (Iandiorio, course director)

Fall 2017, Infectious disease block, UME Phase 2, PBL tutorials 10 sessions (Iandiorio, course director)

Fall 2016, Infectious disease block, UME Phase 2, PBL tutorials 10 sessions (Iandiorio, course director)

Fall 2014, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)

Fall 2013, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)


Fall 2012, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)

Fall 2011, Immunology block, UME Phase 1, PBL tutorials (Checkarian, course director)

Winter 2010, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials (Mold, course director)

Winter 2009, Infection and Immunity tutorial block, UME Phase 1. 4 lectures, PBL tutorials (Mold, course director)

Winter 2008, Infection and Immunity tutorial block, UME Phase 1. 4 lectures, PBL tutorials (Mold, course director)

Winter 2007, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials, (Mold, course director)

Winter 2006, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials (Mold, course director)

Winter 2005, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials Mold, course director)

Winter 2004, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials Mold, course director)

Winter 2003, Infection and Immunity tutorial block, UME Phase 1. PBL tutorials Mold, course director)

BSGP

2002-2006 BSGP BIOMED 525

2002-2006 BSGP BIOMED 508

研究と奨学金

デレティック博士の科学への主な貢献は、感染と免疫におけるオートファジーの役割に関する彼のチームによる最初の報告と継続的な追跡調査から来ており、彼と彼のグループは(他の人たちとともに)この分野を開拓し、急成長している分野に発展させました研究の。 デレティック博士の研究の影響の歴史的背景は、デレティック博士の研究以前のオートファジーが代謝と細胞質品質管理におけるその役割に限定されていたことを理解することによって最もよく理解されます(Klionsky&DereticによるNature Reviewsポスターを参照してください: http://www.nature.com/nrm/posters/autophagy/index.html). Dr. Deretic’s work on autophagy in immunity coincides with the beginnings of the appreciation of autophagy’s role in human health (1a). Dr. Deretic’s group is one of those that made the discovery that autophagy is a major effector and regulator of immunity (see sections 2,4, and 5 below). A series of invited reviews over past 10 years by Deretic and colleagues attest to the role that Dr. Deretic has played in developing this field and includes the first recognition of the broadly integrated role of autophagy in immunity as well as the most recent summaries of the role of autophagy in immunity and inflammation (1b-d). For other representative primary publications and a breakdown of specific subsets of research contributions in this area see sections 2-5, below.
a. Deretic V, Klionsky DJ. How cells clean house. Sci Am. 2008 May;298(5):74-81. PubMed PMID: 18444328.
b. Deretic V, Saitoh T, Akira S. Autophagy in infection, inflammation and immunity. Nat Rev Immunol. 2013 Oct;13(10):722-37. PubMed PMID: 24064518.
c. Rubinsztein, DC, Bento, CF, Deretic, V. Therapeutic targeting of autophagy in neurodegenerative and infectious diseases. J Exp Med, 2015, Jun 29;212(7):979-990. PMID: 26101267.
d. Deretic V. Autophagy in leukocytes and other cells: mechanisms, subsystem organization, selectivity, and links to innate immunity. Journal of Leukocyte Biology. 2016; 100(5):969-978. PMID: 27493243.